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Jee Yon Kim et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2012)
Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow
Paul L. DeAngelis
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2012)
Exploring the effect of mild hypothermia on CHO cell productivity
Silvana Becerra et al.
BIOCHEMICAL ENGINEERING JOURNAL (2012)
Mammalian cell protein expression for biopharmaceutical production
Jianwei Zhu
BIOTECHNOLOGY ADVANCES (2012)
Construction of BAC-based physical map and analysis of chromosome rearrangement in chinese hamster ovary cell lines
Yihua Cao et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
Inhibition of glutamine-dependent autophagy increases t-PA production in CHO Cell fed-batch processes
Mario A. Jardon et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
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BIOTECHNOLOGY AND BIOENGINEERING (2012)
The characterization and quantitation of glycomic changes in CHO cells during a bioreactor campaign
Samnang Tep et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
Differential in-gel electrophoresis (DIGE) analysis of CHO cells under hyperosmotic pressure: Osmoprotective effect of glycine betaine addition
Jee Yon Kim et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics
Paula Meleady et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
Metabolite profiling of CHO cells with different growth characteristics
Stefanie Dietmair et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
A screening method to assess biological effects of microRNA overexpression in Chinese hamster ovary cells
Vaibhav Jadhav et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
Profiling conserved microRNA expression in recombinant CHO cell lines using illumina sequencing
Stephanie Hammond et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture
Suresh Selvarasu et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
Dynamic mRNA and miRNA profiling of CHO-K1 suspension cell cultures
Juan A. Hernandez Bort et al.
BIOTECHNOLOGY JOURNAL (2012)
Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines
Padraig Doolan et al.
BIOTECHNOLOGY JOURNAL (2012)
A mechanistic study on the effect of dexamethasone in moderating cell death in Chinese Hamster Ovary cell cultures
Ying Jing et al.
BIOTECHNOLOGY PROGRESS (2012)
Effect of process parameters and product-host-interaction on hVEGFA-production by recombinant Chinese hamster ovary cells
Denise Freimark et al.
BIOTECHNOLOGY PROGRESS (2012)
Effect of hydrocortisone on the production and glycosylation of an Fc-fusion protein in CHO cell cultures
Yolande Rouiller et al.
BIOTECHNOLOGY PROGRESS (2012)
Effects of clonal variation on growth, metabolism, and productivity in response to trophic factor stimulation: a study of Chinese hamster ovary cells producing a recombinant monoclonal antibody
Hussain Dahodwala et al.
CYTOTECHNOLOGY (2012)
Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells
Paula Meleady et al.
JOURNAL OF BIOTECHNOLOGY (2012)
Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines
Matthias Hackl et al.
JOURNAL OF BIOTECHNOLOGY (2012)
Growth, productivity and protein glycosylation in a CHO EpoFc producer cell line adapted to glutamine-free growth
Michael Taschwer et al.
JOURNAL OF BIOTECHNOLOGY (2012)
Proteomic Analysis of Chinese Hamster Ovary Cells
Deniz Baycin-Hizal et al.
JOURNAL OF PROTEOME RESEARCH (2012)
Systems metabolic engineering of microorganisms for natural and non-natural chemicals
Jeong Wook Lee et al.
NATURE CHEMICAL BIOLOGY (2012)
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
Thomas Gaj et al.
NATURE METHODS (2012)
Expanding the chemical palate of cells by combining systems biology and metabolic engineering
Kathleen A. Curran et al.
METABOLIC ENGINEERING (2012)
Metabolic engineering of Chinese hamster ovary cells: Towards a bioengineered heparin
Jong Youn Baik et al.
METABOLIC ENGINEERING (2012)
Flow-cytometry and cell sorting: An efficient approach to investigate productivity and cell physiology in mammalian cell factories
Niraj Kumar et al.
METHODS (2012)
Monitoring of autophagy in Chinese hamster ovary cells using flow cytometry
Jae Seong Lee et al.
METHODS (2012)
Identification of cell culture conditions to control protein aggregation of IgG fusion proteins expressed in Chinese hamster ovary cells
Ying Jing et al.
PROCESS BIOCHEMISTRY (2012)
Engineering genes for predictable protein expression
Claes Gustafsson et al.
PROTEIN EXPRESSION AND PURIFICATION (2012)
Combinatorial engineering of ldh-a and bcl-2 for reducing lactate production and improving cell growth in dihydrofolate reductase-deficient Chinese hamster ovary cells
Min Kyoung Jeon et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)
Conserved MicroRNAs in Chinese Hamster Ovary Cell Lines
Kathryn C. Johnson et al.
BIOTECHNOLOGY AND BIOENGINEERING (2011)
Selection of CHO Host Cell Subclones With Increased Specific Antibody Production Rates by Repeated Cycles of Transient Transfection and Cell Sorting
Johannes Pichler et al.
BIOTECHNOLOGY AND BIOENGINEERING (2011)
A Review of the Mammalian Unfolded Protein Response
Anirikh Chakrabarti et al.
BIOTECHNOLOGY AND BIOENGINEERING (2011)
Development and characterization of a Chinese hamster ovary cell-specific oligonucleotide microarray
Mark Melville et al.
BIOTECHNOLOGY LETTERS (2011)
Profiling Highly Conserved MicroRNA Expression in Recombinant IgG-Producing and Parental Chinese Hamster Ovary Cells
Nan Lin et al.
BIOTECHNOLOGY PROGRESS (2011)
Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype
Paula Meleady et al.
BMC BIOTECHNOLOGY (2011)
Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy
George Silva et al.
CURRENT GENE THERAPY (2011)
Regulation of Rad51 function by phosphorylation
Sonja Flott et al.
EMBO REPORTS (2011)
In Vitro Micronucleus Screening of Pharmaceutical Candidates by Flow Cytometry in Chinese Hamster V79 Cells
John Nicolette et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2011)
Enhanced sialylation of recombinant human erythropoietin in Chinese hamster ovary cells by combinatorial engineering of selected genes
Young-Dok Son et al.
GLYCOBIOLOGY (2011)
Identification of Poly (ADP-ribose) Polymerase-1 (PARP-1) as a Novel Kruppel-like Factor 8-interacting and -regulating Protein
Heng Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering
Matthias Hackl et al.
JOURNAL OF BIOTECHNOLOGY (2011)
Predicting cell-specific productivity from CHO gene expression
Colin Clarke et al.
JOURNAL OF BIOTECHNOLOGY (2011)
Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7
N. Barron et al.
JOURNAL OF BIOTECHNOLOGY (2011)
Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases
Meixia Zhou et al.
JOURNAL OF BIOTECHNOLOGY (2011)
The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
Xun Xu et al.
NATURE BIOTECHNOLOGY (2011)
Length-dependent translation of messenger RNA by ribosomes
Angelo Valleriani et al.
PHYSICAL REVIEW E (2011)
Exploiting Nucleotide Composition to Engineer Promoters
Manfred G. Grabherr et al.
PLOS ONE (2011)
Design of Experiment in CHO and HEK transient transfection condition optimization
Frederic Bollin et al.
PROTEIN EXPRESSION AND PURIFICATION (2011)
A high-throughput method for quantification of glycoprotein sialylation
Lam Raga A. Markely et al.
ANALYTICAL BIOCHEMISTRY (2010)
Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol
Stefanie Dietmair et al.
ANALYTICAL BIOCHEMISTRY (2010)
Array-Based Analysis of Secreted Glycoproteins for Rapid Selection of a Single Cell Producing a Glycoprotein with Desired Glycosylation
Sunyoung Park et al.
ANALYTICAL CHEMISTRY (2010)
BAK and BAX Deletion Using Zinc-Finger Nucleases Yields Apoptosis-Resistant CHO Cells
Gregory J. Cost et al.
BIOTECHNOLOGY AND BIOENGINEERING (2010)
A DIGE Approach for the Assessment of Differential Expression of the CHO Proteome Under Sodium Butyrate Addition: Effect of Bcl-xL Overexpression
Jong Youn Baik et al.
BIOTECHNOLOGY AND BIOENGINEERING (2010)
A GFP-based method facilitates clonal selection of transfected CHO cells
Denise Freimark et al.
BIOTECHNOLOGY JOURNAL (2010)
Combining High-Throughput Screening of Caspase Activity with Anti-Apoptosis Genes for Development of Robust CHO Production Cell Lines
Haimanti Dorai et al.
BIOTECHNOLOGY PROGRESS (2010)
Maximizing Productivity of CHO Cell-Based Fed-Batch Culture Using Chemically Defined Media Conditions and Typical Manufacturing Equipment
Yao-Ming Huang et al.
BIOTECHNOLOGY PROGRESS (2010)
Cell Engineering and Cultivation of Chinese Hamster Ovary (CHO) Cells
Takeshi Omasa et al.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2010)
Glycomics Profiling of Chinese Hamster Ovary Cell Glycosylation Mutants Reveals N-Glycans of a Novel Size and Complexity
Simon J. North et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment
Anne Kantardjieff et al.
JOURNAL OF BIOTECHNOLOGY (2010)
Biopharmaceutical benchmarks 2010
Gary Walsh
NATURE BIOTECHNOLOGY (2010)
Meganuclease-Driven Targeted Integration in CHO-K1 Cells for the Fast Generation of HTS-Compatible Cell-Based Assays
Jean-Pierre Cabaniols et al.
JOURNAL OF BIOMOLECULAR SCREENING (2010)
Proteomic Profiling of a High-Producing Chinese Hamster Ovary Cell Culture
Tyler Carlage et al.
ANALYTICAL CHEMISTRY (2009)
Effective Quenching Processes for Physiologically Valid Metabolite Profiling of Suspension Cultured Mammalian Cells
Christopher A. Sellick et al.
ANALYTICAL CHEMISTRY (2009)
Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments
Sung Hyun Kim et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2009)
RNA interference technology to improve recombinant protein production in Chinese hamster ovary cells
Suh-Chin Wu
BIOTECHNOLOGY ADVANCES (2009)
Enhanced sialylation of recombinant erythropoietin in genetically engineered Chinese-hamster ovary cells
Yeon Tae Jeong et al.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2009)
Expression of Anti-Apoptosis Genes Alters Lactate Metabolism of Chinese Hamster Ovary Cells in Culture
Haimanti Dorai et al.
BIOTECHNOLOGY AND BIOENGINEERING (2009)
A Predictive High-Throughput Scale-Down Model of Monoclonal Antibody Production in CHO Cells
Rachel Legmann et al.
BIOTECHNOLOGY AND BIOENGINEERING (2009)
Mcl-1 Overexpression Leads to Higher Viabilities and Increased Production of Humanized Monoclonal Antibody in Chinese Hamster Ovary Cells
Brian S. Majors et al.
BIOTECHNOLOGY PROGRESS (2009)
A Single Nutrient Feed Supports Both Chemically Defined NS0 and CHO Fed-Batch Processes: Improved Productivity and Lactate Metabolism
Ningning Ma et al.
BIOTECHNOLOGY PROGRESS (2009)
Methodological Aspects of Measuring Absolute Values of Membrane Potential in Human Cells by Flow Cytometry
Thomas Klapperstueck et al.
CYTOMETRY PART A (2009)
Lessons learned from the contamination of heparin
Haiying Liu et al.
NATURAL PRODUCT REPORTS (2009)
Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells
Warren Pilbrough et al.
PLOS ONE (2009)
Orthogonal analytical approaches to detect potential contaminants in heparin
Marco Guerrini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture
William P. K. Chong et al.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2009)
How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes
Yanfang Guo et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2008)
Quality Assessment of Cross-Species Hybridization of CHO Transcriptome on a Mouse DNA Oligo Microarray
Joon Chong Yee et al.
BIOTECHNOLOGY AND BIOENGINEERING (2008)
The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells
Jong Hyun Nam et al.
BIOTECHNOLOGY AND BIOENGINEERING (2008)
Genomic and proteomic exploration of CHO and hybridoma cells under sodium butyrate treatment
Joon Chong Yee et al.
BIOTECHNOLOGY AND BIOENGINEERING (2008)
Sodium butyrate stimulates monoclonal antibody over-expression in CHO cells by improving gene accessibility
Zhou Jiang et al.
BIOTECHNOLOGY AND BIOENGINEERING (2008)
Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells
Chaya Mohan et al.
Biotechnology Journal (2008)
Proteomic profiling of secreted proteins from CHO cells using surface-enhanced laser desorption ionization time-of-flight mass spectrometry
Niraj Kumar et al.
BIOTECHNOLOGY PROGRESS (2008)
Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1
Frederik Eisele et al.
FEBS LETTERS (2008)
Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol
Paula Meleady et al.
PROTEOMICS (2008)
Generation of High-Level Stable Transgene Expressing Human Embryonic Stem Cell Lines Using Chinese Hamster Elongation Factor-1α Promoter System
Ken Kwok-Keung Chan et al.
STEM CELLS AND DEVELOPMENT (2008)
MicroRNAs as targets for engineering of CHO cell factories
Dethardt Mueller et al.
TRENDS IN BIOTECHNOLOGY (2008)
Short hairpin RNA targeted to dihydrofolate reductase enhances the immunoglobulin G expression in gene-amplified stable Chinese hamster ovary cells
Suh-Chin Wu et al.
VACCINE (2008)
In pursuit of a super producer - alternative paths to high producing recombinant mammalian cells
Gargi Seth et al.
CURRENT OPINION IN BIOTECHNOLOGY (2007)
Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells
Pierre-Alain Girod et al.
NATURE METHODS (2007)
Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin
Yun Hee Sung et al.
METABOLIC ENGINEERING (2007)
Engineering cell metabolism for high-density cell culture via manipulation of sugar transport
Katie F. Wlaschin et al.
JOURNAL OF BIOTECHNOLOGY (2007)
Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells
Patrick Gammell et al.
JOURNAL OF BIOTECHNOLOGY (2007)
A novel RNA silencing vector to improve antigen expression and stability in Chinese hamster ovary cells
Willy W. L. Hong et al.
VACCINE (2007)
An efficient and targeted gene integration system for high-level antibody expression
Ying Huang et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2007)
Using cell engineering and omic tools for the improvement of cell culture processes
Darrin Kuystermans et al.
CYTOTECHNOLOGY (2007)
Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes
Paula Meleady
CYTOTECHNOLOGY (2007)
Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin
Sung Hyun Kim et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2007)
Advancing mammalian cell culture engineering using genome-scale technologies
Timothy J. Griffin et al.
TRENDS IN BIOTECHNOLOGY (2007)
Selection methods for high-producing mammalian cell lines
Susan M. Browne et al.
TRENDS IN BIOTECHNOLOGY (2007)
RNAi suppression of Bax and Bak enhances viability in fed-batch cultures of CHO cells
Sing Fee Lim et al.
METABOLIC ENGINEERING (2006)
Targeting early apoptotic genes in batch and fed-batch CHO cell cultures
Danny Chee Furng Wong et al.
BIOTECHNOLOGY AND BIOENGINEERING (2006)
Post-translational modifications in the context of therapeutic proteins
Gary Walsh et al.
NATURE BIOTECHNOLOGY (2006)
Transcriptome and proteome profiling to understanding the biology of high productivity CHO cells
Peter Morin Nissom et al.
MOLECULAR BIOTECHNOLOGY (2006)
RNA interference of sialidase improves glycoprotein sialic acid content consistency
Frederyk A. Ngantung et al.
BIOTECHNOLOGY AND BIOENGINEERING (2006)
Antibody production
John R. Birch et al.
ADVANCED DRUG DELIVERY REVIEWS (2006)
Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation
Yoshikatsu Kaneko et al.
SCIENCE (2006)
Enhancing recombinant glycoprotein sialylation through CMP-sialic acid transporter over expression in chinese hamster ovary cells
NSC Wong et al.
BIOTECHNOLOGY AND BIOENGINEERING (2006)
Control of translation and mRNA degradation by miRNAs and siRNAs
MA Valencia-Sanchez et al.
GENES & DEVELOPMENT (2006)
Employing epigenetics to augment the expression of therapeutic proteins in mammalian cells
THJ Kwaks et al.
TRENDS IN BIOTECHNOLOGY (2006)
Initial transcriptome and proteome analyses of low culture temperature-induced expression in CHO cells producing erythropoietin
JY Baik et al.
BIOTECHNOLOGY AND BIOENGINEERING (2006)
Transient gene expression in suspension HEK-293 cells: Application to large-scale protein production
L Baldi et al.
BIOTECHNOLOGY PROGRESS (2005)
Dynamics of single cell property distributions in Chinese hamster ovary cell cultures monitored and controlled with automated flow cytometry
J Kacmar et al.
JOURNAL OF BIOTECHNOLOGY (2005)
EST sequencing for gene discovery in Chinese hamster ovary cells
KF Wlaschin et al.
BIOTECHNOLOGY AND BIOENGINEERING (2005)
Influence of down-regulation of caspase-3 by siRNAs on sodium-butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin
YH Sung et al.
METABOLIC ENGINEERING (2005)
Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals
M Butler
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2005)
Glycoengineering: The effect of glycosylation on the properties of therapeutic proteins
AM Sinclair et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Use of the chicken lysozyme 5′ matrix attachment region to generate high producer CHO cell lines
PA Girod et al.
BIOTECHNOLOGY AND BIOENGINEERING (2005)
High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-1α gene
JR Deer et al.
BIOTECHNOLOGY PROGRESS (2004)
Improved recombinant gene expression in CHO cells using matrix attachment regions
JM Kim et al.
JOURNAL OF BIOTECHNOLOGY (2004)
Establishment of FUT8 knockout Chinese hamster ovary cells:: An ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity
N Yamane-Ohnuki et al.
BIOTECHNOLOGY AND BIOENGINEERING (2004)
Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA
K Mori et al.
BIOTECHNOLOGY AND BIOENGINEERING (2004)
The roles of enzyme localisation and complex formation in glycan assembly within the Golgi apparatus
CL de Graffenried et al.
CURRENT OPINION IN CELL BIOLOGY (2004)
Production of recombinant protein therapeutics in cultivated mammalian cells
FM Wurm
NATURE BIOTECHNOLOGY (2004)
Role of glycosylation indevelopment
RS Haltiwanger et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2004)
Identification of anti-repressor elements that confer high and stable protein production in mammalian cells
THJ Kwaks et al.
NATURE BIOTECHNOLOGY (2003)
High-level expression of recombinant IgG in the human cell line PER.C6
D Jones et al.
BIOTECHNOLOGY PROGRESS (2003)
High-throughput clonal selection of recombinant CHO cells using a dominant selectable and amplifiable metallothionein-GFP fusion protein
CG Bailey et al.
BIOTECHNOLOGY AND BIOENGINEERING (2002)
Construction of engineered CHO strains for high-level production of recombinant proteins
M Kito et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2002)
The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein
T Benton et al.
CYTOTECHNOLOGY (2002)
Characterization of the stability of recombinant protein production in the GS-NS0 expression system
LM Barnes et al.
BIOTECHNOLOGY AND BIOENGINEERING (2001)
Development of stable cell lines for production or regulated expression using matrix attachment regions
M Zahn-Zabal et al.
JOURNAL OF BIOTECHNOLOGY (2001)
The gel microdrop secretion assay: Identification of a low productivity subpopulation arising during the production of human antibody in CHO cells
L Hammill et al.
CYTOTECHNOLOGY (2000)
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