期刊
EMERGING INFECTIOUS DISEASES
卷 24, 期 7, 页码 1292-1299出版社
CENTERS DISEASE CONTROL
DOI: 10.3201/eid2407.172128
关键词
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资金
- Academy of Finland [1257964, 277590]
- Jane and Aatos Erkko Foundation
- Sigrid Juselius Foundation
- Medical Society of Finland
- Research Funds of the University of Helsinki
- Helsinki University Hospital Research and Education Fund
- Life and Health Medical Grant Association
- Finnish Work Environment Fund
- Clinical Chemistry Foundation
- Biomedicum Helsinki Foundation
- Finnish Society for Study of Infectious Diseases
- Otto A. Malm Foundation
- Jenny and Antti Wihuri Foundation
- Orion-Farmos Research Foundation
- Center for International Mobility, Finland
Development of next-generation sequencing and metagenomics has revolutionized detection of novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus, tusavirus, and cutavirus. These viruses have been detected in feces of children with diarrhea. In addition, cutavirus has been detected in skin biopsy specimens of cutaneous T-cell lymphoma patients in France and in 1 melanoma patient in Denmark. We studied seroprevalences of IgG against bufavirus, tusavirus, and cutavirus in various populations (n = 840), and found a striking geographic difference in prevalence of bufavirus IgG. Although prevalence was low in adult populations in Finland (1.9%) and the United States (3.6%), bufavirus IgG was highly prevalent in populations in Iraq (84.8%), Iran (56.1%), and Kenya (72.3%). Conversely, cutavirus IgG showed evenly low prevalences (0%-5.6%) in all cohorts, and tusavirus IgG was not detected. These results provide new insights on the global distribution and endemic areas of protoparvoviruses.
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