期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1422, 期 -, 页码 1-12出版社
ELSEVIER
DOI: 10.1016/j.chroma.2015.10.007
关键词
Double-sided magnetic molecularly imprinted polymer modified graphene oxide; Magnetic solid-phase extraction; Trace analysis; Microcystins; Environmental water; LC-MS/MS
资金
- National Natural Science Foundation of China [21377114]
- Zhejiang Provincial Medical Health Platform Project of China [2015RCB023]
- Zhejiang Provincial Program for Public Welfare of Technology Application Research Plan [2015C31148]
- Ningbo Natural Science Foundation of China [2013A610242]
- Natural Science Foundation of Zhejiang Province [LY12H26003, LY14B070004, LY14B040003]
- Constructive Major Project for the Department of Health and Family Planning Commission-Zhejiang Province [2014PYA019]
- Group of Scientific and Technical Innovation of Ningbo [2015C110019]
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents
Microcystins (MCs), a group of cyclic heptapeptide heaptoxins and tumor promoters, are generated by cyanobacteria occurring in surface waters, such as eutrophic lakes, rivers, and reservoirs. In this present study, a novel double-sided magnetic molecularly imprinted polymer modified graphene oxide (DS-MMIP@GO) based magnetic solid-phase extraction (MSPE) method was developed for fast, effective and selective enrichment, and recognition of trace MCs in environmental water samples combined with high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The synthesized novel DS-MMIP@GO was used as the adsorbents in this work and was carefully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and Raman spectra. The adsorption and desorption conditions of DS-MMIP@GO toward MCs were optimized in detail to obtain the highest binding capacity, selectivity, and release efficiency. Under the optimum conditions, the enrichment factors of the method for eight target MCs were found to be 2000. The limits of quantitation (LOQs) of the method for eight MCs were in range of 0.1-2.0 ng L-1. The double-sided MMIP modified structure provided DS-MMIP@GO with abundant adsorption sites and permitted it to exhibit excellent enrichment and selectivity toward trace-level MCs. The proposed method was successfully applied for the analysis of environmental water samples with recoveries ranging from 84.1 to 98.2%. Compared to conventional methods for MCs detection reported in literatures, the one developed in this work based on DS-MMIP@GO and LC-MS/MS showed much faster, more sensitive, and more convenient. (C) 2015 Elsevier B.V. All rights reserved.
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