期刊
THERANOSTICS
卷 8, 期 21, 页码 6053-6069出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.30305
关键词
Rho-associated coiled-coil kinase (ROCK); angiogenesis; endothelial cell; microenvironment; therapeutic target
资金
- Cancer Prevention and Research Institute of Texas [RR140081, RR170721]
- National Natural Science Foundation of China [81700319, 81570255]
- Key Science and Technology Research Plan of Shandong Province [2017GSF218037]
- Shandong Taishan Scholarship
Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the process of generating new capillaries from the pre-existing ones, is required for the development of various diseases such as cancer, diabetes and rheumatoid arthritis. Recently, ROCK has attracted attention for its crucial role in angiogenesis, making it a promising target for new therapeutic approaches. In this review, we summarize recent advances in understanding the role of ROCK signaling in regulating the permeability, migration, proliferation and tubulogenesis of endothelial cells (ECs), as well as its functions in non-ECs which constitute the pro-angiogenic microenvironment. The therapeutic potential of ROCK inhibitors in angiogenesis-related diseases is also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据