期刊
BIOTECHNOLOGY AND BIOENGINEERING
卷 101, 期 4, 页码 850-858出版社
WILEY
DOI: 10.1002/bit.21952
关键词
boron nitride nanotubes; biocompatibility; quantum dots; cell uptake; endocytosis
资金
- IIT (Italian Institute of Technology) Network
- NINIVE (Non-Invasive Nanotransducer for In Vivo gene thErapy [STRP 033378]
- 6FP of the European Commission
Boron nitride nanotubes (BNNTs) have unique physical properties, which can be exploited in the biomedical field. Hence, the surprising lack of reported studies on their biocompatibility and interactions with living cells, addressed by the present paper which deals the results of such an investigation based on 72 h culture of human neuroblastoma cell line (SH-SY5Y) in the presence of an aqueous suspension of polyethyleneimine (PEI)-coated BNNTs. BNNTs conjugated with fluorescent markers (quantum dots) are employed to enable tracking of their uptake by living cells. The results demonstrate good cyto-compatibility together with unequivocal BNNT cellular uptake by an energy-dependent endocytic process.
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