期刊
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
卷 60, 期 1, 页码 92-101出版社
WILEY-BLACKWELL
DOI: 10.1002/bab.1088
关键词
P450; aromatase; catalysis; crystal structure; estrogens
Aromatase (CYP19) is involved in steroidogenesis, catalyzing the conversion of androgens into estrogens through a unique reaction that causes the aromatization of the A ring of the steroid. The enzyme is widely distributed and well conserved among species as it plays a crucial role in physiological processes such as control of reproduction and neuroprotection. It has also been a subject of intense research both at the biotechnological level in drug development due to its involvement in estrogen-dependent tumors and at a fundamental biochemical level because there are numerous questions regarding its reaction mechanism. This review will report the great progress made in this area.
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