期刊
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
卷 60, 期 2, 页码 266-273出版社
WILEY
DOI: 10.1002/bab.1064
关键词
scaffold; carbonate apatite layer; Ca; P molar ratio; selective laser sintering; simulated body fluid (SBF); weight loss
资金
- Natural Science Foundation of China [51222506, 81000972]
- Foundation for the Author of National Excellent Doctoral Dissertation of PR China [201032]
- Program for New Century Excellent Talents in University [NCET-10-0792]
- Fundamental Research Funds for the Central Universities [2011JQ005]
- Fok Ying-Tong Education Foundation, China [131050]
- Open Research Fund of State Key Laboratory of Transient Optics and Photonics, Chinese Academy of Sciences
- Open-End Fund for the Valuable and Precision Instruments of Central South University
Porous scaffolds consisting of -tricalcium phosphate (-TCP) were successfully fabricated via selective laser sintering. The scaffolds had a controlled microstructure and totally interconnected porous structure. The microstructure and mechanical properties were studied. The bioactivity and degradability of scaffolds were evaluated through the simulated body fluid (SBF) cultivation experiment. The formation of a biologically active carbonate apatite layer on the surface after immersion in SBF was demonstrated using scanning electron microscope, energy dispersive X-ray, and Fourier transform infrared spectroscopy. Fast nucleation and growth of the carbonate apatite crystals were observed to occur all through the specimen surfaces. The phenomenon was explained in terms of the distribution and dispersion of inorganic phases in the scaffolds and the ionic activity products of the apatite in the SBF. The calculation results of weight loss and Ca/P molar ratio also suggest the good bioactivity and degradability of the scaffolds. These indicate that the -TCP porous ceramic scaffold is a potential candidate scaffold for bone tissue engineering.
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