期刊
BIOTECHNOLOGY ADVANCES
卷 32, 期 4, 页码 818-830出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2013.12.008
关键词
Gene therapy; Gene vectors; Gene transfection; Functionalization; Dendritic polymers; Dendrimer; Biodegradable; Biocompatibility
资金
- National Natural Science Foundation of China [51133004, 81361140343, 51373104, 81101099]
- National Basic Research Program of China (National 973 program) [2011CB606206]
- Excellent Young Teachers Program of Sichuan University [2012SCU04A06]
- Biomedical Materials Data Sharing Resource Node [2009DKA-1]
Gene therapy has provided great potential to revolutionize the treatment of many diseases. This therapy is strongly relied on whether a delivery vector efficiently and safely directs the therapeutic genes into the target tissue/cells. Nonviral gene delivery vectors have been emerging as a realistic alternative to the use of viral analogs with the potential of a clinically relevant output. Dendritic polymers were employed as nonviral vectors due to their branched and layered architectures, globular shape and multivalent groups on their surface, showing promise in gene delivery. In the present review, we try to bring out the recent trend of studies on functional and biodegradable dendritic polymers as nontoxic and efficient gene delivery vectors. By regulating dendritic polymer design and preparation, together with recent progress in the design of biodegradable polymers, it is possible to precisely manipulate their architectures, molecular weight and chemical composition, resulting in predictable tuning of their biocompatibility as well as gene transfection activities. The multifunctional and biodegradable dendritic polymers possessing the desirable characteristics are expected to overcome extra- and intracellular obstacles, and as efficient and nontoxic gene delivery vectors to move into the clinical arena. (C) 2014 Elsevier Inc. All rights reserved.
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