期刊
BIOTECHNOLOGY ADVANCES
卷 32, 期 4, 页码 778-788出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2013.10.002
关键词
Nanoparticle; Drug delivery; Lipid; Calcium phosphate; Nanocrystals; siRNA; Polymer; Gold nanoparticle; Liposome
资金
- NIH [CA129835, CA129421, CA151652, CA151455, CA149363]
Nanoparticle drug formulations have been extensively researched and developed in the field of drug delivery as a means to efficiently deliver insoluble drugs to tumor cells. By mechanisms of the enhanced permeability and retention effect, nanoparticle drug formulations are capable of greatly enhancing the safety, pharmacokinetic profiles and bioavailability of the administered treatment Here, the progress of various nanoparticle formulations in both research and clinical applications is detailed with a focus on the development of drug/gene delivery systems. Specifically, the unique advantages and disadvantages of polymeric nanoparticles, liposomes, solid lipid nanoparticles, nanocrystals and lipid-coated nanoparticles for targeted drug delivery will be investigated in detail. (C) 2013 Published by Elsevier Inc. All rights reserved.
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