期刊
BIOTECHNOLOGY ADVANCES
卷 32, 期 4, 页码 711-726出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2013.11.006
关键词
Nanoparticle; Nanomedicine; Physicochemical properties; Image contrast agents; Molecular imaging
资金
- NIH/National Institute of Minority Health Disparities [G12 MD007597]
- US Army Medical Research and Material Command [W81XWH-10-1-0767]
Advances in nanotechnology have opened up a new era of diagnosis, prevention and treatment of diseases and traumatic injuries. Nanomaterials, including those with potential for clinical applications, possess novel physicochemical properties that have an impact on their physiological interactions, from the molecular level to the systemic level. There is a lack of standardized methodologies or regulatory protocols for detection or characterization of nanomaterials. This review summarizes the techniques that are commonly used to study the size, shape, surface properties, composition, purity and stability of nanomaterials, along with their advantages and disadvantages. At present there are no FDA guidelines that have been developed specifically for nanomaterial based formulations for diagnostic or therapeutic use. There is an urgent need for standardized protocols and procedures for the characterization of nanoparticles, especially those that are intended for use as theranostics. (C) 2013 Published by Elsevier Inc.
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