期刊
BIOTECHNOLOGY ADVANCES
卷 32, 期 2, 页码 255-268出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2013.10.008
关键词
Streptomyces species; Secondary metabolites; Systems biology; Systems biotechnology; Systems metabolic engineering; Omits techniques; Databases; Knowledgebases; Constraint-based flux analysis
资金
- Novo Nordisk Foundation
- Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation (NRF) of Korea [NRF-2012-C1AAA001-2012M1A2A2026556]
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
- National Research Foundation of Korea [2012M1A2A2026557] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolisms at the genome scale. Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism. Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species. (C) 2013 Elsevier Inc All rights reserved.
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