期刊
BIOTECHNOLOGY ADVANCES
卷 31, 期 8, 页码 1224-1236出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2013.03.005
关键词
Surface modification; Iron oxide nanoparticles; Biocompatible polymer; Tissue imaging; Targeting
资金
- Bio Imaging Research Center at GIST
- Regional Technology Innovation Program of the Ministry of Commerce, Industry and Energy [RT104-01-01]
- Basic Science Research Program through the National Research Foundation of Korea
- Ministry of Education, Science and Technology [2010-0002940]
- Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea [A120899]
- Small and Medium Business Administration of Korea
- Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology (MEST) [2011-0030034]
- Future Pioneer R&D program through the National Research Foundation of Korea
- Ministry of Education, Science, and Technology [2012-0001034]
- Ministry of Science & ICT (MSIT), Republic of Korea [GIST-12] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2011-0030034, 2010-0002940, 2009-0082952] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Superparamagnetic iron oxide nanoparticles (SPIONs) are excellent MR contrast agents when coated with biocompatible polymers such as hydrophilic synthetic polymers, proteins, polysaccharides, and lipids, which improve their stability and biocompatibility and reduce their aggregation. Various biocompatible materials, coated or conjugated with targeting moieties such as galactose, mannose, folic acid, antibodies and RGD, have been applied to SPION surfaces to provide tissue specificity to hepatocytes, macrophages, and tumor regions in order to reduce non-specific uptake and improve biocompatibility. This review discusses the recent progress in the development of biocompatible and hydrophilic polymers for improving stability of SPIONs and describes the carbohydrates based biocompatible materials that are providing SPIONs with cell/tissue specificity as ligands. (C) 2013 Elsevier Inc. All rights reserved.
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