期刊
BIOTECHNOLOGY ADVANCES
卷 31, 期 5, 页码 669-687出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2012.11.007
关键词
Tissue engineering; Fiber-based techniques; Scaffold fabrication; Cell-laden constructs
资金
- NSERC
- CIHR
- CHRP
- CFI
- Genome Canada
- Genome Quebec
- Canada Research Chair
- National Science Foundation Career Award [DMR 0847287]
- office of Naval Research Young National Investigator Award
- National Institutes of Health [HL092836, DE019024, EB012597, AR057837, DE021468, HL099073, EB008392]
- Fonds Quebecois de la Recherche sur la Nature et les Technologies (FRSQ Canada)
Tissue engineering aims to improve the function of diseased or damaged organs by creating biological substitutes. To fabricate a functional tissue, the engineered construct should mimic the physiological environment including its structural, topographical, and mechanical properties. Moreover, the construct should facilitate nutrients and oxygen diffusion as well as removal of metabolic waste during tissue regeneration. In the last decade, fiber-based techniques such as weaving, knitting, braiding, as well as electrospinning, and direct writing have emerged as promising platforms for making 3D tissue constructs that can address the abovementioned challenges. Here, we critically review the techniques used to form cell-free and cell-laden fibers and to assemble them into scaffolds. We compare their mechanical properties, morphological features and biological activity. We discuss current challenges and future opportunities of fiber-based tissue engineering (FBTE) for use in research and clinical practice. (c) 2012 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据