期刊
BIOTECHNOLOGY ADVANCES
卷 30, 期 6, 页码 1602-1613出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2012.05.004
关键词
Genetic engineering; Transgenic algae; Marine algae; Genomics; Vector; Expression system; Photobioreactor; Biosafety
资金
- SOA Public Science and Technology Research Funds Projects of Ocean [20120527, 200905021-3]
- NSFC general program [41176144]
- CAS/SAFEA International Partnership Program for Creative Research Teams 'Typical Process in Coastal Zone Area and Its Effects on Bio-resources' [KZCX2-YW-T14]
- '973' program of China [2011CB200902]
- '863' Program of China [2009AA10Z106]
- Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province [2010BSB02009]
- NSF of Shandong Province [JQ200914, 2009ZRB02542]
Algae are a component of bait sources for animal aquaculture, and they produce abundant valuable compounds for the chemical industry and human health. With today's fast growing demand for algae biofuels and the profitable market for cosmetics and pharmaceuticals made from algal natural products, the genetic engineering of marine algae has been attracting increasing attention as a crucial systemic technology to address the challenge of the biomass feedstock supply for sustainable industrial applications and to modify the metabolic pathway for the more efficient production of high-value products. Nevertheless, to date, only a few marine algae species can be genetically manipulated. In this article, an updated account of the research progress in marine algal genomics is presented along with methods for transformation. In addition, vector construction and gene selection strategies are reviewed. Meanwhile, a review on the progress of bioreactor technologies for marine algae culture is also revisited. (c) 2012 Elsevier Inc. All rights reserved.
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