期刊
BIOTECHNOLOGY ADVANCES
卷 29, 期 6, 页码 997-1003出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2011.08.021
关键词
Secreted reporter; Gaussia luciferase; SEAP; Soluble peptides; Imaging; Blood assay
资金
- National Institutes of Health
- National Cancer Institute [4R00CA126839]
- National Institute of Neurological Disorders and Stroke [NS045776, 1R01NS064983]
Secreted reporters detected in body fluids (blood, serum or urine) have shown to be simple and useful tools for ex vivo real-time monitoring of in vivo biological processes. Here we explore the most commonly used secreted blood reporters in experimental animals: secreted alkaline phosphatase, soluble marker peptides derived from human carcinoembryonic antigen and human chorionic gonadotropin, as well as Gaussia luciferase. We also comment on other recently discovered secreted luciferases and their potential use as blood reporters for multiplexing applications. (C) 2011 Elsevier Inc. All rights reserved.
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