期刊
BIOTECHNOLOGY ADVANCES
卷 28, 期 6, 页码 694-705出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2010.05.002
关键词
Laccase; Natural mediators; Phenolic compounds; Oxidation mechanisms; Bioremediation; Lignin biodegradation; Lignocellulose biorefinery
资金
- BIORENEW [NMP2-CT-2006-026456]
- [CTQ2005-08925-CO2-02]
Laccases are oxidoreductases which oxidize a variety of aromatic compounds using oxygen as the electron acceptor and producing water as by-product. The interest for these old enzymes (first described in 19th century) has progressively increased due to their outstanding biotechnological applicability. The presence of redox mediators is required for a number of biotechnological applications, providing the oxidation of complex substrates not oxidized by the enzyme alone. The efficiency of laccase-mediator systems to degrade recalcitrant compounds has been demonstrated, but still the high cost and possible toxicity of artificial mediators hamper their application at the industrial scale. Here, we present a general outlook of how alternative mediators can change this tendency. We focus on phenolic compounds related to lignin polymer that promotes the in vitro transformation of recalcitrant non-phenolic structures by laccase and are seemingly the natural mediators of laccases. The use of eco-friendly mediators easily available from lignocellulose, could contribute to the industrial implementation of laccases and the development of the 21th century biorefineries. (C) 2010 Elsevier Inc. All rights reserved.
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