期刊
FRONTIERS IN VETERINARY SCIENCE
卷 5, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2018.00276
关键词
badger; model; decision making; bovine tuberculosis; simulation
Computer modeling has a long history of association with epidemiology, and has improved our understanding of the theory of disease dynamics and provided insights into wildlife disease management. A summary of badger bovine TB models and their role in decision making is presented, from a simple initial SEI model, to SEIR (inclusion of a recovered category) and SEI1I2 (inclusion of two stages of disease progression) variants, and subsequent spatially-explicit individual-based models used to assess historical badger management strategies. The integration of cattle into TB models allowed comparison of the predicted impacts of different badgermanagement strategies on cattle herd breakdown rates, and provided an economic dimension to the outputs. Estimates of R-0 for bovine TB in cattle and badgers are little higher than unity implying that the disease should be relatively easy to control, which is at odds with practical experience. A cohort of recent models have suggested that combined strategies, involving management of both host species and including vaccination may be most effective. Future models of badger vaccination will need to accommodate the partial protection from infection and likely duration of immunity conferred by the currently available vaccine (BCG). Descriptions of how models could better represent the ecological and epidemiological complexities of the badger-cattle TB system are presented, along with a wider discussion of the utility of modeling for bovine TB management interventions. This includes consideration of the information required to maximize the utility of the next generation of models.
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