期刊
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 34, ISSUE 2
卷 34, 期 2, 页码 153-180出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02648725.2018.1471566
关键词
LncRNA; cancer; gene regulation; molecular mechanism
Long noncoding RNAs (lncRNAs) are non-protein-coding RNA transcripts that exert a key role in many cellular processes and have potential toward addressing disease etiology. Here, we review existing noncoding RNA classes and then describe a variety of mechanisms and functions by which lncRNAs regulate gene expression such as chromatin remodeling, genomic imprinting, gene transcription and post-transcriptional processing. We also examine several lncRNAs that contribute significantly to pathogenesis, oncogenesis, tumor suppression and cell cycle arrest of diverse cancer types and also give a summary of the pathways that lncRNAs might be involved in.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据