期刊
NEUROPSYCHIATRIC DISEASE AND TREATMENT
卷 14, 期 -, 页码 647-655出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NDT.S159322
关键词
major depressive disorder; MDD; gut microbiota; biomarker
资金
- Natural Science Foundation Project of China [81701360, 81601208, 81771490]
- Chongqing Science and Technology Commission [cstc2017j-cyjA0207, cstc2014kjrc-qnrc10004]
- Science and Technology Research Program of Chongqing Municipal Education Commission [KJ1702037]
- Special Project on Natural Chronic Noninfectious Diseases [2016YFC1307200]
- National Key Research and Development Program of China [2017YFA0505700]
- National Basic Research Program of China (973 Program) [2009CB918300]
Objective: Our previous studies found that disturbances in gut microbiota might have a causative role in the onset of major depressive disorder (MDD). The aim of this study was to investigate whether there were sex differences in gut microbiota in patients with MDD. Patients and methods: First-episode drug-naive MDD patients and healthy controls were included. 16S rRNA gene sequences extracted from the fecal samples of the included subjects were analyzed. Principal-coordinate analysis and partial least squares-discriminant analysis were used to assess whether there were sex-specific gut microbiota. A random forest algorithm was used to identify the differential operational taxonomic units. Linear discriminant-analysis effect size was further used to identify the dominant sex-specific phylotypes responsible for the differences between MDD patients and healthy controls. Results: In total, 57 and 74 differential operational taxonomic units responsible for separating female and male MDD patients from their healthy counterparts were identified. Compared with their healthy counterparts, increased Actinobacteria and decreased Bacteroidetes levels were found in female and male MDD patients, respectively. The most differentially abundant bacterial taxa in female and male MDD patients belonged to phyla Actinobacteria and Bacteroidia, respectively. Meanwhile, female and male MDD patients had different dominant phylotypes. Conclusion: These results demonstrated that there were sex differences in gut microbiota in patients with MDD. The suitability of Actinobacteria and Bacteroidia as the sex-specific biomarkers for diagnosing MDD should be further explored.
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