期刊
GENETICS
卷 210, 期 2, 页码 653-663出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.118.301444
关键词
Blimp-1; Drosophila; trachea; chitin; Btk29A; aECM
资金
- IRB-La Caixa fellowship
- Generalitat de Catalunya
- Spanish Ministerio de Ciencia e Innovacion [BFU2009-07629]
- Ramon y Cajal [RYC-2007-00417]
The specification of tissue identity during embryonic development requires precise spatio-temporal coordination of gene expression. Many transcription factors required for the development of organs have been identified and their expression patterns are known; however, the mechanisms through which they coordinate gene expression in time remain poorly understood. Here, we show that hormone-induced transcription factor Blimp-1 participates in the temporal coordination of tubulogenesis in Drosophila melanogaster by regulating the expression of many genes involved in tube maturation. In particular, we demonstrate that Blimp-1 regulates the expression of genes involved in chitin deposition and F-actin organization. We show that Blimp-1 is involved in the temporal control of lumen maturation by regulating the beginning of chitin deposition. We also report that Blimp-1 represses a variety of genes involved in tracheal maturation. Finally, we reveal that the kinase Btk29A serves as a link between Blimp-1 transcriptional repression and apical extracellular matrix organization.
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