期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 75, 期 8, 页码 1377-1391出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2725-4
关键词
Bone marrow niche; Myeloid malignancies; Leukemic-initiating cells; Mesenchymal stroma cells
资金
- Francis Crick Institute from Cancer Research UK [FC001045]
- UK Medical Research Council [FC001045]
- Welcome Trust [FC001045]
- Minister of research, Paris Diderot University, France
- Cancer Research UK [15692] Funding Source: researchfish
- The Francis Crick Institute [10045] Funding Source: researchfish
The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells (HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into the role of the BMM and its cellular and molecular actors in the progression of the diseases have started to emerge. In this review, we will focus on describing the major players of the HSC niche and the role of the altered niche function in myeloid malignancies, more specifically focusing on the mesenchymal stroma cell compartment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据