期刊
ENEURO
卷 5, 期 2, 页码 -出版社
SOC NEUROSCIENCE
DOI: 10.1523/ENEURO.0109-18.2018
关键词
degeneration; MANF; neuroprotection; photoreceptor; retina; RGC
资金
- National Institutes of Health (NIH) [R01EY015289, R01EY018586]
- Hope for Vision
- James and Esther King Biomedical Research Program of the State of Florida [08KN-09, 2KF02]
- National Natural Science Foundation of China [81560164, 81300737]
- NIH [P30EY14801, P30EY002162]
- Research to Prevent Blindness Inc.
- Nelson Trust Award for Retinitis Pigmentosa from Research to Prevent Blindness, Inc.
- NATIONAL EYE INSTITUTE [R01EY015289, P30EY002162, P30EY014801, R01EY018586] Funding Source: NIH RePORTER
Retinal degenerations are a major cause of vision impairment and blindness. Neuroprotective therapy is a promising therapeutic strategy for retinal degenerative diseases. We investigated a novel neurotrophic factor mesencephalic astrocyte-derived neurotrophic factor (MANF) in the retina. MANF is expressed at a high level during postnatal development and the expression declines to a lower level as the retina matures. Muller cells are the major cells expressing MANF. It is also found in the retinal ganglion cells, in the inner nuclear layer (INL) neurons, and in retinal pigment epithelial (RPE) cells. Intravitreal injection of recombinant human (rh) MANF significantly protected rod and cone photoreceptors in rats carrying the rhodopsin S334ter mutation, and preserved electroretinograms (ERGs) in the rd10 (Pde6b(rd10/rd10)) mice. These results indicate that MANF is a native protein in the retina and is a potent neurotrophic factor for photoreceptor protection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据