期刊
MATERIALS CHEMISTRY FRONTIERS
卷 2, 期 10, 页码 1893-1899出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qm00309b
关键词
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资金
- Ministry of Science and Technology of China [2014CB239402, 2017YFA0206903]
- National Natural Science Foundation of China [21474124, 21390404, 91427303]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB17000000]
- Key Research Program of Frontier Sciences of the Chinese Academy of Sciences [QYZDY-SSW-JSC029]
- K. C. Wong Education Foundation
Hydrogen-bonded supramolecular polymer nanoparticles (SPNPs), serving as a ratiometric oxygen nanoprobe for hypoxia sensing and photodynamic therapy (PDT) treatment, were designed. Herein, oxygen-sensitive phosphorescent Pt(II) porphyrin moiety and oxygen-insensitive fluorescent 9,10-diphenylanthracene moiety were assembled through quadruple hydrogen bonding into SPNPs. The efficient energy transfer between the monomeric donor-acceptor pairs in the SPNPs Leads to enhanced phosphorescence with long lifetimes. The resulting bright phosphorescence can realize hypoxia sensing in living cells and generate singlet oxygen efficiently in SPNPs to kill cancer cells. This is the first example of a multi-functional supramolecular polymer-based nanoprobe for ratiometric hypoxia sensing, imaging and PDT treatment.
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