期刊
BIOSYSTEMS
卷 114, 期 3, 页码 206-213出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2013.05.008
关键词
DNA computing; Molecular pattern classification; Non-linear classification; Molecular beacons; Biological data analysis
资金
- Ministry of Knowledge Economy (MKE) through the Molecular Evolutionary Computing (MEC) project
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science & Technology (MEST) [0421-20110032]
- BK21-IT Program
In vitro pattern classification has been highlighted as an important future application of DNA computing. Previous work has demonstrated the feasibility of linear classifiers using DNA-based molecular computing. However, complex tasks require non-linear classification capability. Here we design a molecular beacon that can interact with multiple targets and experimentally shows that its fluorescent signals form a complex radial-basis function, enabling it to be used as a building block for non-linear molecular classification in vitro. The proposed method was successfully applied to solving artificial and real-world classification problems: XOR and microRNA expression patterns. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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