期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1406, 期 -, 页码 279-290出版社
ELSEVIER
DOI: 10.1016/j.chroma.2015.06.011
关键词
Chemical warfare agents; Gas chromatography-mass spectrometry; On-site detection; Micro-concentration; Carry-over; Gasoline interference
A field-portable gas chromatograph-mass spectrometer (Hapsite ER system) was evaluated for the detection of chemical warfare agents (CWAs) in the vapor phase. The system consisted of Tr-Bed concentrator gas sampler (trapping time: 3 s(-1) min), a nonpolar low thermal-mass capillary gas chromatography column capable of raising temperatures up to 200 degrees C, a hydrophobic membrane-interfaced electron ionization quadrupole mass spectrometer evacuated by a non-evaporative getter pump for data acquisition, and a personal computer for data analysis. Sample vapors containing as little as 22 mu g sarin (GB), 100 mu g soman (GD), 210 mu g tabun (GA), 55 mu g cyclohexylsarin (GF), 4.8 mu g sulfur mustard, 390 mu g nitrogen mustard 1, 140 mu g of nitrogen mustard 2, 130 mu g nitrogen mustard 3, 120 mu g of 2-chloroacetophenone and 990 mu g of chloropicrin per cubic meter could be confirmed after Tr-Bed micro-concentration (for I min) and automated AMDIS search within 12 min. Using manual deconvolution by background subtraction of neighboring regions on the extracted ion chromatograms, the above-mentioned CWAs could be confirmed at lower concentration levels. The memory effects were also examined and we found that blister agents showed significantly more carry-over than nerve agents. Gasoline vapor was found to interfere with the detection of GB and GD, raising the concentration limits for confirmation in the presence of gasoline by both AMDIS search and manual deconvolution; however, GA and GF were not subject to interference by gasoline. Lewisite 1, and o-chlorobenzylidene malononitrile could also be confirmed by gas chromatography, but it was hard to quantify them. Vapors of phosgene, chlorine, and cyanogen chloride could be confirmed by direct mass spectrometric detection at concentration levels higher than 2, 140, and 10 mg/m(3) respectively, by bypassing the micro-concentration trap and gas chromatographic separation. (C) 2015 Elsevier B.V. All rights reserved.
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