期刊
RESPIRATORY RESEARCH
卷 19, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12931-018-0750-y
关键词
Cystic fibrosis; Animal models; Lung disease; Pathology
资金
- NHMRC [APP1098127]
- Women's and Children's Hospital Foundation
- MS McLeod PhD Scholarship
- Cure4CF Foundation
In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection, inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary manifestations in CF mouse models has hindered investigations of airway disease pathogenesis, as well as the development and testing of potential therapeutics. However, recently generated CF animal models including rat, ferret and pig models demonstrate a range of well characterised lung disease phenotypes with varying degrees of severity. This review discusses the airway phenotypes of currently available CF animal models and presents potential applications of each model in airway-related CF research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据