期刊
CHEMICAL REVIEWS
卷 118, 期 1, 页码 73-118出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.6b00824
关键词
-
资金
- Biotechnology and Biological Sciences Research Council [BB/K00199X/1] Funding Source: Medline
- BBSRC [BB/K00199X/1] Funding Source: UKRI
Ammonia-lyases and aminomutases are mechanistically and structurally diverse enzymes which catalyze the deamination and/or isomerization of amino acids in nature by cleaving or shifting a C-N bond. Of the many protein families in which these enzyme activities are found, only a subset have been employed in the synthesis of optically pure fine chemicals or in medical applications. This review covers the natural diversity of these enzymes, highlighting particular enzyme classes that are used within industrial and medical biotechnology. These highlights detail the discovery and mechanistic investigations of these commercially relevant enzymes, along with comparisons of their various applications as stand-alone catalysts, components of artificial biosynthetic pathways and biocatalytic or chemoenzymatic cascades, and therapeutic tools for the potential treatment of various pathologies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据