期刊
CELLULAR AND MOLECULAR BIOLOGY
卷 64, 期 5, 页码 46-51出版社
C M B ASSOC
DOI: 10.14715/cmb/2018.64.5.7
关键词
PTPN22; Autoimmune diseases; Meta-analysis
资金
- [NRF-2017M3A9B4050335]
This study explored whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) G788A(R263Q) polymorphism is associated with susceptibility to autoimmune diseases. A meta-analysis was conducted using 23 comparative studies with a total of 16,719 patients and 17,783 controls. The meta analysis showed an association between the A allele of the PTPN22 C1788A polymorphism and decreased risk of autoimmune diseases in all subjects (p < 0.001). Analysis after stratification by ethnicity indicated that the PTPN22 788A allele was significantly associated with autoimmune diseases in Europeans (p < 0.001) hut not in Latin Americans. Meta-analysis by autoimmune disease type showed a significant negative association between the PTPN22 788A allele and systemic lupus erythematous (SLE) (p = 001), rheumatoid arthritis (RA) (p = 0.008), ulcerative colitis (UC) (p = 0.016), but not Crohn's disease (CD). A single study for each showed no association between the PTPN22 788A allele and systemic sclerosis, giant cell arteritis, Henoch-schonlein purpura, uveitis, and Grave's disease. This meta-analysis demonstrates that the PTPN22 0788A polymorphism confers protection against SLE, RA, and UC, supporting evidence of association of the PTPN22 gene with a subgroup of autoimmune diseases.
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