期刊
BIOSENSORS & BIOELECTRONICS
卷 57, 期 -, 页码 48-53出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.01.028
关键词
Giant magnetoresistance; Biosensor; Cell counting; Cell separation
类别
资金
- ROC National Science Council [NSC 99-2112-M-007-016-MY3, NSC 99-2112-M-007-015-MY3, NSC 102-2112-M-007-006-MY3, NSC 102-2112-M-007-012-MY3]
A Wheatstone bridge giant magnetoresistance (GMR) biosensor was proposed here for the detection and counting of magnetic cells. The biosensor was made of a top-pinned spin-valve layer structure, and it was integrated with a microchannel possessing the function of hydrodynamic focusing that allowed the cells to flow in series one by one and ensured the accuracy of detection. Through measuring the magnetoresistance variation caused by the stray field of the magnetic cells that flowed through the microchannel above the GMR biosensor, we can not only detect and count the cells but we can also recognize cells with different magnetic moments. In addition, a magnetic field gradient was applied for the separation of different cells into different channels. (c) 2014 Elsevier B.V. All rights reserved.
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