期刊
BIOSENSORS & BIOELECTRONICS
卷 56, 期 -, 页码 91-96出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.01.017
关键词
Glucose sensor; Bovine serum; PANI; PLGA
类别
资金
- National Key Technology R&D Program of China [2012BAI16B02]
- National Natural Science Foundation of China [81171416, 60875078]
Glucose sensors with long life span were fabricated and evaluated in 37 degrees C serum to imitate in vivo conditions. Polyaniline nanofibers were electrodeposited on sensor electrodes for excessive glucose oxidase immobilization to extend the lifetime of sensors. The sensitivity of sensors stored in 37 degrees C bovine serum was stable for 20 days without apparent descents, and still remained 45% of its initial value after 44 days. In order to further improve the life span of sensors, a degradable polymer film, poly lactic-co-glycolic acid (PLGA), was used as an out coating layer of glucose sensors. Results showed that the PLGA coated glucose sensors left 80% of its initial sensitivity after 44 days' storage in 37 degrees C bovine serum. The sensors could be potentially used as long-term implantable devices for real time monitoring of glucose levels. (C) 2014 Elsevier B.V. All rights reserved.
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