期刊
BIOSENSORS & BIOELECTRONICS
卷 59, 期 -, 页码 293-299出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.03.070
关键词
Biosensors; Glucose oxidase; Liquid crystals; PH-driven phenomenon; Optical response
类别
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF2013R1A1A1A05008333]
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [H113C0891]
Glucose is an extremely important biomolecule, and the ability to sense it has played a significant role in facilitating the understanding of many biological processes. Here, we report a novel glucose sensor based on ultraviolet (UV)-treated nematic liquid crystals. Submerging UV-treated 4-cyano-4'-pentylbiphenyl (5CB) in a glucose solution (while carefully adjusting its pH to 7.5 with NaOH and HCI) triggered an optical response, from dark to bright, observed with a polarized microscope. Notably, 5CB was located inside a glucose oxidase (GOx)-modified gold grid. We exploited this pH-driven phenomenon to design a new glucose sensor. This device could detect as little as 1 pM analyte, which is 3 orders of magnitude lower than the detection limit of the most sensitive glucose sensor currently available. It also exhibits high selectivity due to GOx modification. Thus, this is a promising technique for glucose detection, not only for clinical diagnostics, but also for sensing low levels of glucose in a biological environment (e.g., single cells and bacterial cultures). (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据