期刊
BIOSENSORS & BIOELECTRONICS
卷 60, 期 -, 页码 143-153出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.03.044
关键词
Impedance spectroscopy; Neural probe; Microelectrodes array; Mouse brain; Cortical layers; Thermal cauterization
类别
资金
- Stoicescu Foundation and Brazilian Swiss Joint Research Programme [BJRP 0112-09]
Electrical impedance spectroscopy measurements were performed in post-mortem mice brains using a flexible probe with an embedded micrometric electrode array. Combined with a peak resistance frequency method this allowed obtaining intrinsic resistivity values of brain tissues and structures with submillimetric resolution. Reproducible resistivity measurements are reported, which allows the resistivity in the cortex, ventricle, fiber tracts, thalamus and basal ganglia to be differentiated. Measurements of brain slices revealed resistivity profiles correlated with the local density of cell bodies hence allowing to discriminate between the different cortical layers. Finally, impedance measurements were performed on a model of cauterized mouse brain evidencing the possibility to measure the spatial extent and the degree of the tissue denaturation due to the cauterization. (C) 2014 Elsevier B.V. All rights reserved.
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