期刊
BIOSENSORS & BIOELECTRONICS
卷 60, 期 -, 页码 101-111出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.03.057
关键词
Field-effect transistor; Biosensor; Surface modification; Sensitivity enhancement
类别
资金
- Ministry of Science and Technology of Taiwan [NSC 101-2120-M-009-011-CC1]
- Center for Multidisciplinary Science of National Chiao Tung University, Taiwan
Silicon nanowire field effect transistors (SiNW-FETs) have shown great promise as biosensors in highly sensitive, selective, real-time and label-free measurements. While applications of SiNW-FETs for detection of biological species have been described in several publications, less attention has been devoted to summarize the conjugating methods involved in linking organic bio-receptors with the inorganic transducer and the strategies of improving the sensitivity of devices. This article attempts to focus on summarizing the various organic immobilization approaches and discussing various sensitivity improving strategies, that include (I) reducing non-specific binding, (II) alignment of the probes, (III) enhancing signals by charge reporter, (IV) novel architecture structures, and (V) sensing in the subthreshold regime. (C) 2014 Elsevier B.V. All rights reserved.
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