期刊
BIOSENSORS & BIOELECTRONICS
卷 41, 期 -, 页码 889-893出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2012.09.060
关键词
Graphene oxide; Mercury; Sensor; Fluorescence; Detection
类别
资金
- NSF [CBET-0754405, EPS 1003907]
- Research Challenge Grant from the State of West Virginia [EPS08-01]
- West Virginia University Research Corporation
- West Virginia EPSCoR Office
- Office of Integrative Activities
- Office Of The Director [1003907] Funding Source: National Science Foundation
Label-free fluorescent detection of Hg2+ has been realized via quenching of fluorescence of graphene oxide (GO). The water-soluble GO sheets, which are functionalized with single-stranded DNA aptamer, exhibit strong fluorescence emission at 600 nm under the excitation of 488 nm in the absence of He ions. When Hg2+ ions appear in the aqueous solution, Hg2+ ions are sandwiched between the hairpin-shaped double-stranded DNA due to the formation of the thymine-Hg2+-thymine complex, which holds the Hg2+ ions in proximity to the surface of GO sheets. As a result, the fluorescence emission of GO is quenched. The present GO-based sensor shows a limit of detection as low as 0.92 nM and excellent selectivity toward Hg2+ over a wide range of metal ions. The present work indicates that GO is a promising fluorescent probe for detection of metal ions and biomolecules. (C) 2012 Elsevier B.V. All rights reserved.
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