期刊
BIOSENSORS & BIOELECTRONICS
卷 45, 期 -, 页码 25-33出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.01.036
关键词
SiO2-coated graphene oxide; Molecularly imprinted polymers; Electrochemical sensor; Dopamine
类别
资金
- National Natural Science Foundation of China [21175044, 21275055, 21277048]
- Programs of the Science & Technology Commission of Shanghai Municipality [10JC1404000]
- Natural Science Foundation of Shanghai [11ZR1410700]
- Research Fund for the Doctoral Program of Higher Education [20100076110002]
A novel imprinting route based on graphene oxide (GO) was proposed for preparing a composite of SiO2-coated GO and molecularly imprinted polymers (GO/SiO2-MIPs). In this route, SiO2-coated GO sheets were synthesized in a water-alcohol mixture with sol-gel technique. Prior to polymerization, the vinyl groups were introduced onto the surface of GO/SiO2 through chemical modification with gamma-methacryloxypropyl trimethoxysilane (gamma-MAPS), which can direct the selective polymerization on the GO/SiO2 surface. Then a novel composite of GO/SiO2-MIPs was successfully obtained by the copolymerization in presence of vinyl groups functionalized GO/SiO2, dopamine (DA), methacrylic acid and ethylene glycol dimethacrylate. The GO/SiO2-MIP5 composite was characterized by FTIR, TGA, Raman spectroscopy, SEM and AFM. The properties such as special binding, adsorption dynamics and selective recognition ability using differential pulse voltammetry (DPV) were evaluated. The DPV current response of GO/SiO2-MIPs sensor was nearly 3.2 times that of the non-imprinted polymers (NIPs). In addition, the GO/SiO2-MIPs sensor could recognize DA from its relatively similar molecules of norepinephrine and epinephrine, while the sensors based on GO/SiO2-NIPs and vinyl groups functionalized GO/SiO2 did not have the ability. The GO/SiO2-MIPs sensor had a wide linear range over DA concentration from 5.0 x 10(-8) to 1.6 x 10(-4) M with a detection limit of 3.0 x 10(-8) M (S/N=3). The sensor based on this novel imprinted composite was applied to the determination of DA in injections and human urine samples with satisfactory results. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据