期刊
BIOSENSORS & BIOELECTRONICS
卷 49, 期 -, 页码 512-518出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.05.021
关键词
Glucose; Surface acoustic wave (SAW); ZnO; Glucose oxidase functional immobilization; Biosensor
类别
资金
- National Hi-tech (R&D) project of China [2009AA034001]
- National Natural Science Foundation of China [11174208]
- Basical Research Program of Shenzhen [JC201104210094A, JCYJ20120817163755062]
- Natural Science Foundation of SZU [801 00035699]
This work reports a high-performance Mn-doped ZnO multilayer structure Love mode surface acoustic wave (SAW) biosensor for the detection of blood sugar. The biosensor was functionalized via immobilizing glucose oxidase onto a pH-sensitive polymer which was attached on Mn-doped ZnO biosensor. The fabricated SAW glucose biosensor is highly sensitive, accurate and fast with good anti-interference. The sensitivity of the SAW glucose biosensor is 7.184 MHz/mM and the accuracy is 6.96 x 10(-3) mM, which is sensitive and accurate enough for glucose monitoring. A good degree of reversibility and stability of the glucose sensor is also demonstrated, which keeps a constant differential frequency shift up to 32 days. Concerning the time response to human serum, the glucose sensor shows a value of 4.6 +/- 0.4 min when increasing glucose concentrations and 7.1 +/- 0.6 mm when decreasing, which is less than 10 min and reach the fast response requirement for medical applications. The Mn-doped ZnO Love mode SAW biosensor can be fully integrated with CMOS Si chips and developed as a portable, passive and wireless real time detection system for blood sugar monitoring in human serum. (c) 2013 Elsevier B.V. All rights reserved.
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