期刊
BIOSENSORS & BIOELECTRONICS
卷 47, 期 -, 页码 1-11出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.02.045
关键词
Electrochemical immunosensor (EI); Point of care (POC); Oriented immobilization; Nanotechnology; Multiplexing analysis; Integration
类别
资金
- National Science Foundation [21105048, 21205079]
- NUST [2011XQTR08]
- Shanghai Bureau of Quality and Technical Supervision [2012-04]
- General Administration of Quality Supervision, Inspection and Quarantine of PRC [2012QK273]
Electrochemical immunosensors (El) has attracted numerous interests due to its inherent benefits over the other transduction schemes, such as a high sensitivity, ease of use, a possible automation and integration in compact analytical devices, mostly cheap and relatively simple technology of its production. Thus, EIs have great potential in point of care (POC) diagnostics for early detection of diseases. During last decades, numerous efforts have been put into EIs development. Firstly, different fabrication methods and amplification strategies have been employed to achieve high sensitivity. To be pointed, nanotechnology has been involved in the fabrication and signal amplification of EIs, which present great superiority. Secondly, El arrays have been used for multiparametric analysis. Thirdly, several attempts have been made to construct integrated systems, which showed promising applications for POC test. Several of them are commercially available for POC use. Herein, we will review briefly the recent achievements and progress in developing EIs towards POC diagnostics. (C) 2013 Elsevier B.V. All rights reserved.
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