期刊
BIOSENSORS & BIOELECTRONICS
卷 47, 期 -, 页码 68-74出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.02.048
关键词
Amorphous carbon; Magnetic composite nanomaterials; Electrochemiluminescence; Immunosensor; Carcinoembryonic antigen
类别
资金
- Natural Science Research Foundation of China [51273084, 21277058, 21207048]
- Technology Development Plan of Shandong Province, China [2012GGB01181, 2011GGB01153]
- Natural Science Foundation of Shandong Province, China [ZR2011BQ019, ZR 2012BZ002]
In this paper, a carbon coated magnetic nanoparticle (Fe3O4-C) was first synthesized via solvothermal reaction and carbonization of glucose under hydrothermal condition. The electrochemiluminescence (ECL) property of Fe3O4-C was studied, and exhibited a peak at 1.21 V. In the goal to amplify the ECL intensity for sensitive detection, a novel coaxial carbon coated magnetic nanomaterial (MWNTs-Fe3O4-C) was synthesized. Fourier transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), powder X-ray diffraction (XRD) and powder X-ray photoelectron spectrometry (XPS) were applied as powerful tools to characterize and to demonstrate the named nanomaterial. MWNTs-Fe3O4-C showed better ECL property than Fe3O4-C. Furthermore, an ultrasensitive ECL immunosensor based on MWNTs-Fe3O4-C was developed for the determination of carcinoembryonic antigen (CEA). The prepared ECL immunosensor exhibited high sensitivity, good reproducibility, long-term stability, and acceptable precision on the detection of CEA in clinical human serum samples. (C) 2013 Elsevier B.V. All rights reserved.
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