期刊
BIOSENSORS & BIOELECTRONICS
卷 26, 期 5, 页码 2766-2771出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2010.10.027
关键词
MIP; Electropolymerization; Surface plasmon resonance (SPR) sensing; Naproxen; Paracetamol; Theophylline
类别
资金
- NSF [CBET-0854979, DMR-10-06776]
- Robert A. Welch Foundation [E-1551]
A novel chemosensitive ultrathin film with high selectivity was developed for the detection of naproxen, paracetamol, and theophylline using non-covalent electropolymerized molecular imprinted polymers (E-MIP). A series of monofunctional and bifunctional H-bonding terthiophene and carbazole monomers were compared for imprinting these drugs without the use of a separate cross-linker. A key step is the fast and efficient potentiostatic method of washing the template, which facilitated enhanced real-time sensing by surface plasmon resonance (SPR) spectroscopy. Various surface characterizations (contact angle, ellipsometry, XPS, AFM) of the E-MIP film verified the templating and release of the drug from the cross-linked conducting polymer film. (c) 2010 Elsevier B.V. All rights reserved.
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