期刊
CELL AND TISSUE RESEARCH
卷 371, 期 1, 页码 73-89出版社
SPRINGER
DOI: 10.1007/s00441-017-2641-9
关键词
Notch signaling; Neurogenesis; Epigenetic regulation; Pathway cross-talk; Brain disorders
类别
资金
- Swiss National Science Foundation
- SystemsX.ch
- NeuroStemX project
- University of Basel
- Forschungsfond of the University of Basel
Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the adult brain. Notch functions greatly depend on careful regulation and cross-talk with other regulatory mechanisms. Deregulation of Notch signaling is involved in many neurodegenerative diseases and brain disorders. Here, we summarize the fundamental role of Notch in neuronal development and specification and discuss how epigenetic regulation and pathway cross-talk contribute to Notch function. In addition, we cover aberrant alterations of Notch signaling in the diseased brain. The aim of this review is to provide an insight into how Notch signaling works in different contexts to control neurogenesis and its potential effects in diagnoses and therapies of neurodegeneration, brain tumors and disorders.
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