期刊
BIOSENSORS & BIOELECTRONICS
卷 29, 期 1, 页码 172-177出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2011.08.013
关键词
Bacillus anthracis; Europium; Polyacrylonitrile; Nanoparticles; Fluorescence
类别
资金
- WCU (World Class University) through the National Research Foundation of Korea
- Ministry of Education, Science and Technology [R31-10013]
- National Research Foundation of Korea [R31-2011-000-10013-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Novel fluorescent polyacrylonitrile nanoparticles were synthesized by microemulsion polymerization and Schiff base modification. By further modification with europium, the polyacrylonitrile nanoparticles could be used as a highly sensitive and rapid sensor for Bacillus anthracis spore detection in aqueous solution. The europium-modified polyacrylonitrile nanoparticles were readily combined with dipicolinic acid as a unique biomarker of B. anthracis, leading to high fluorescence emission. These nanoparticles enabled ratiometric detection without instrument-specific calibration due to the internal fluorescence reference. Additionally, the europium-modified polyacrylonitrile nanoparticle sensors exhibited a remarkable limit of detection (10 pM) for dipicolinic acid and outstanding selectivity (160x) over aromatic ligands in aqueous solution. The ultrafine nanoparticle sensor showed a high capability for detecting anthrax due to the increased surface area-to-volume ratio and enhanced dispersibility. (C) 2011 Elsevier B.V. All rights reserved.
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