Metal ion mediated imprinting for electrochemical enantioselective sensing of L-histidine at trace level

Enantioselective trace level sensing of L-histidine (limit of detection, 1.980 ng mL(-1), S/N = 3) was feasible with the use of a typical, reproducible, and rugged complex imprinted polymer-based pencil graphite electrode, in aqueous samples. In the present instance, the Cu2+ ion-mediated imprinting of L-histidine in an molecularly imprinted polymer motif actually helped upbringing electrocatalytic activity to respond an enhanced differential pulse anodic stripping voltammetric oxidation peak of L-histidine, without any cross-reactivity and false-positive, in real samples. The proposed sensor could be considered suitable for the practical applications in biomarking histedinemia, a disease associated with L-histidine metabolic disorders, in clinical settings. (C) 2011 Elsevier B.V. All rights reserved.