期刊
BIOSENSORS & BIOELECTRONICS
卷 26, 期 5, 页码 2107-2113出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2010.09.015
关键词
Biosensing; Ubiquitous sensing; Optical sensing; High dynamic range imaging; Distributed sensing; Distributed diagnostics
类别
资金
- Carl Trygger Foundation of Sweden
- Thammasat University of Thailand
The determination of NT-proBNP levels is key for the monitoring of patients with diagnosed heart failure and it is a routine measurement typically performed at health care centers, which would benefit from decentralized alternatives. Here we investigate the quantitative evaluation of a well-established NT-proBNP test using a standard mobile phone (Nokia 6720) as measuring platform rather than a dedicated instrument. A Java ME software developed for this application controls the illumination and imaging of the proBNP test under defined time intervals, which enables the composition of multi-exposure sets that are processed as high dynamic range (HDR) images for contrast enhancement. The results show that HDR processing significantly increases the sensitivity and resolution of the technique achieving a performance within the diagnostics range. These results demonstrate the feasibility to exploit a ubiquitous device to decentralize the evaluation of a routine test and identify key processing alternatives to bring the performance of such systems within the diagnostics range. (C) 2010 Elsevier B.V. All rights reserved.
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