期刊
BIOSENSORS & BIOELECTRONICS
卷 26, 期 1, 页码 74-79出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2010.05.015
关键词
Self-assembled monolayer; Receptor; Selective recognition by pre-concentration; Serotonin; Electrochemical impedance spectroscopy; Anodic stripping differential pulse voltammetry
类别
资金
- WCU
- POSTECH
We describe a novel medium, a captopril/thiophenol (Capt/TP) mixed self-assembled monolayer (SAM) formed on gold, for selectively pre-concentrating serotonin (5-hydroxytryptamine, 5-HT). The 5-HT molecules were shown to be selectively captured via formation of a strong complex, providing anodic stripping currents upon anodic scan or drastic increases in charge-transfer resistances for a redox probe, Fe(CN)(6)(3-/4-) pair, due to their blocking effects The 5-HT molecules thus collected were subsequently detected by anodic stripping differential pulse voltammetry (ASDPV) or electrochemical impedance spectroscopy (EIS). The detection limit was 1.2 when detected by EIS and 28 nM with ASDPV 5-HT was shown to be determined in physiological matrices containing ascorbic acid, dopamine, and other commonly encountered neurotransmitters (C) 2010 Elsevier B.V. All rights reserved
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