期刊
BIOSENSORS & BIOELECTRONICS
卷 25, 期 7, 页码 1809-1815出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2009.12.037
关键词
Neural interface; Microelectrode array; Vapor-liquid-solid growth; Integrated circuit (IC); MOSFET; Retina
类别
资金
- JSPS
- Ministry of Education, Culture, Sports, Science and Technology Japan
- Japan Science and Technology Agency (JST)
- Strategic Research Program for Brain Sciences (SRPBS)
- Grants-in-Aid for Scientific Research [20226010] Funding Source: KAKEN
We report here a technique for use in electrical interfaces between neurons and microelectronics, using vertically integrated silicon probe arrays with diameters of 2-3.5 mu m and lengths of 60-120 mu m. Silicon probe arrays can be fabricated by selective vapor-liquid-solid (VLS) growth. A doped n-type silicon probe with the resistance of 1 k Omega has an electrical impedance of less than 10 M Omega in physiological saline. After inserting the probe arrays into the retina of a carp (Cyrpinus carpio), we conducted electrical recording of neural signals, using the probes to measure light-evoked electrical neural signals. We determined that recorded signals represented local field potentials of the retina (electroretinogram (ERG)). The VLS-probe can provide minimally invasive neural recording/stimulation capabilities at high spatial resolution for fundamental studies of nervous systems. In addition, the probe arrays can be integrated with microelectronics; therefore, these probes make it possible to construct interfaces between neurons and microelectronics in advanced neuroscience applications. (C) 2010 Elsevier B.V. All rights reserved.
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