期刊
BIOSENSORS & BIOELECTRONICS
卷 25, 期 1, 页码 142-146出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2009.06.022
关键词
Biosensor; Pb nanowires; Gold nanoparticles; Glucose oxidase
类别
资金
- National Natural Science Foundation of China [30772746, 30870665]
- Tianjin Province [08JCZDIC20600]
A novel glucose biosensor was developed, based on the immobilization of glucose oxidase (GOD) with cross-linking in the matrix of bovine serum albumin (BSA) on a Pt electrode, which was modified with gold nanoparticles decorated Pb nanowires (GNPs-Pb NWs). Pb nanowires (Pb NWs) were synthesized by an L-Cysteine-assisted self-assembly route, and then gold nanoparticles (GNPs) were attached onto the nanowire surface through -SH-Au specific interaction. The morphological characterization of GNPs-Pb NWs was examined by transmission electron microscopy (TEM). Cyclic voltammetry and chronoamperometry were used to study and to optimize the electrochemical performance of the resulting biosensor. The synergistic effect of Pb NWs and GNPs made the biosensor exhibit excellent electrocatalytic activity and good response performance to glucose. The effects of pH and applied potential on the amperometric response of the biosensor have been systemically studied. In pH 7.0, the biosensor showed the sensitivity of 135.5 mu A mW(-1) cm(-2), the detection limit of 2 mu M (S/N = 3), and the response time <5 s with a linear range of 5-2200 mu M. Furthermore, the biosensor exhibits good reproducibility, long-term stability and relative good anti-interference. (C) 2009 Elsevier B.V. All rights reserved.
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