期刊
BIOSENSORS & BIOELECTRONICS
卷 24, 期 5, 页码 1241-1245出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2008.07.030
关键词
Organic thin film transistor; Organic semiconductor; DNA sensor
Organic thin film transistors (OTFTs) are excellent candidates for the application on disposable sensors due to their potentially low-cost fabrication process. A novel DNA sensor based on OTFTs with semiconducting polymer poly(3-hexylthiophene) has been fabricated by solution process. Both single- and double-strand DNA molecules are immobilized on the surface of the Au source/drain electrodes of different OTFT devices, producing a dramatic change in the performance of the devices, which is attributed to the increase of the contact resistances at the source/drain electrodes. Single-strand DNA and double-strand DNA are differentiated successfully in the experiments indicating that this is a promising technique for sensing DNA hybridization without labelling. (C) 2008 Elsevier B.V. All rights reserved.
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