期刊
JOURNAL OF DIABETES INVESTIGATION
卷 9, 期 1, 页码 137-145出版社
WILEY
DOI: 10.1111/jdi.12659
关键词
Oral hypoglycemic agents; Randomized controlled study; Treatment satisfaction
资金
- Waksman Foundation of Japan Inc.
- Tenri Hospital
- Nakai Clinic
- Izumi Clinic
- Nara Medical University
- Nijoekimae Clinic
- Yano Clinic
- Hikari Clinic
- Kindai University Nara Hospital
- Nara City Hospital
- Matsumura Clinic
- Nishimoto Medical Clinic
- Sakagami Medical Clinic
- Seiwadai Clinic
- Yashima Medical Clinic
- Kim Clinic
- Sasazuka Inoue Clinic
- Shimomura Clinic
- Tadaoka Clinic
- Wada Clinic
Aims/IntroductionTo compare the treatment satisfaction of four classes of oral hypoglycemic agents (OHAs): dipeptidyl peptidase-4 (DPP-4) inhibitors, -glucosidase inhibitors (GI), biguanides (BG) and sulfonylureas (SU), which are common initial treatments for type 2 diabetes mellitus patients in Japan, and to identify the best oral hypoglycemic agent in terms of treatment satisfaction. Materials and MethodsIn this 12-week, randomized, controlled, open-label study, Japanese outpatients with type 2 diabetes mellitus who were naive to pharmacological treatment were randomly assigned a DPP-4 inhibitor, a BG., an GI or a SU. The primary end-point was the Oral Hypoglycemic Agent Questionnaire (OHA-Q) total and subscale scores (treatment convenience, somatic symptoms and satisfaction) at week 4. Adherence, glycated hemoglobin (HbA1c) level and safety were also evaluated. ResultsThe DPP-4 inhibitor group scored highest in the OHA-Q total and all subscale scores at week 4. The total score was significantly higher in the DPP-4 inhibitor group than in the BG or GI groups (P = 0.0084 and 0.0147, respectively). The mean total score at week 12 was also highest in the DPP-4 inhibitor group, with a significant difference compared with the GI group (P = 0.0293). The mean HbA1c decreased from baseline to week 12 in all groups. The DPP-4 inhibitor group had the highest adherence at weeks 4 and 12. A total of 11 patients reported adverse events, including one hypoglycemic event in the SU group. ConclusionsThe DPP-4 inhibitor was the most preferable option in terms of treatment satisfaction.
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