期刊
ANTIOXIDANTS
卷 7, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/antiox7010016
关键词
mitochondria; oncometabolites; cancer; metabolic re-programming; aerobic glycolysis; mitochondrial dynamics
资金
- University of Kentucky Center for Clinical and Translational Sciences Professional Student Mentored Research Fellowship
- The National Center for Advancing Translational Sciences [UL1TR000117, TL1TR000115, KL2 TR000116]
The mitochondrion is an important organelle and provides energy for a plethora of intracellular reactions. Metabolic dysregulation has dire consequences for the cell, and alteration in metabolism has been identified in multiple disease states-cancer being one. Otto Warburg demonstrated that cancer cells, in the presence of oxygen, undergo glycolysis by reprogramming their metabolism-termed aerobic glycolysis. Alterations in metabolism enable cancer cells to gain a growth advantage by obtaining precursors for macromolecule biosynthesis, such as nucleic acids and lipids. To date, several molecules, termed oncometabolites, have been identified to be elevated in cancer cells and arise from mutations in nuclear encoded mitochondrial enzymes. Furthermore, there is evidence that oncometabolites can affect mitochondrial dynamics. It is believed that oncometabolites can assist in reprogramming enzymatic pathways and providing cancer cells with selective advantages. In this review, we will touch upon the effects of normal and aberrant mitochondrial metabolism in normal and cancer cells, the advantages of metabolic reprogramming, effects of oncometabolites on metabolism and mitochondrial dynamics and therapies aimed at targeting oncometabolites and metabolic aberrations.
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