Insights into the respiratory chain and oxidative stress

Reactive oxygen species (ROS) are highly reactive reduced oxygen molecules that result from aerobic metabolism. The common forms are the superoxide anion (O2(center dot-))and hydrogen peroxide (H2O2) and their derived forms, hydroxyl radical (HO center dot) and hydroperoxyl radical (HOO center dot). Their production sites in mitochondria are reviewed. Even though being highly toxic products, ROS seem important in transducing information from dysfunctional mitochondria. Evidences of signal transduction mediated by ROS in mitochondrial deficiency contexts are then presented in different organisms such as yeast, mammals or photosynthetic organisms.